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In all of these studiesthe main measure of effectiveness was the change in the number of seizures before and during treatment.
In vitro and in vivo recordings of epileptiform activity from the hippocampus have shown that levetiracetam inhibits burst firing without affecting normal neuronal excitabilitysuggesting that levetiracetam may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity.
Keppra tablets are swallowed with liquidThe oral solution may be mixed in a glass of water before it is takenKeppra can be given as an infusion using the same doses at the same frequency when using the tablets or the oral solution is not possibleThe use of the infusion should be temporary.
Standard hemodialysis procedures result in significant clearance of levetiracetamapproximately 50in 4 hoursand should be considered in cases of overdoseAlthough hemodialysis has not been performed in the few known cases of overdoseit may be indicated by the patient’s clinical state or in patients with significant renal impairment.
In controlled clinical studies in adult patients with partial onset seizure studies3.4of adult KEPPRA-treated patients experienced coordination difficultiesreported as either ataxiaabnormal gaitor incoordinationcompared to 1.6of placebo-treated patientsA total of 0.4of patients in controlled clinical studies discontinued KEPPRA treatment due to ataxiacompared to 0of placebo-treated patientsIn 0.7of KEPPRA-treated patients and in 0.2of placebo-treated patientsthe dose was reduced due to coordination difficultieswhile one of the KEPPRA-treated patients was hospitalized due to worsening of pre-existing ataxiaThese events occurred most frequently within the first 4 weeks of treatment.
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