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Patients with baseline neutrophil counts of 80 years of agetreated with XELODA in combination with docetaxel303 out of 10of patients experienced grade 3 or 4 diarrhea and stomatitisand 404 out of 10experienced grade 3 hand-andfoot syndrome.

ClassAntimetabolite chemotherapyFluorouracilGemzarand methotrexate are other antimetabolites.

Patients with baseline neutrophil counts of 80 years of agetreated with XELODA in combination with docetaxel303 out of 10of patients experienced grade 3 or 4 diarrhea and stomatitisand 404 out of 10experienced grade 3 hand-andfoot syndrome.

4Polovich MWhite JMKelleher LOedsChemotherapy and biotherapy guidelines and recommendations for practice2nd ed2005PittsburghPAOncology Nursing Society.

Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

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the recommended dose of xeloda was determined in an open-label, randomized clinical study, exploring the efficacy and safety of continuous therapy with capecitabine 1331 mg m 2 day in two divided doses, n 39 , intermittent therapy with capecitabine 2510 mg m 2 day in two divided doses, n 34 , and intermittent therapy with capecitabine in combination with oral leucovorin lv capecitabine 1657 mg m 2 day in two divided doses, n 35, leucovorin 60 mg day in patients with advanced and or metastatic colorectal carcinoma in the first-line metastatic setting.

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