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Initial monotherapy in patients 2 years of age and older with partial onset or primary generalized tonic-clonic seizuresSafety and effectiveness in patients who were converted to monotherapy from a previous regimen of other anticonvulsant drugs have not been established in controlled trials.

This also varies significantly depending on the individualSome feel the effects within dayswhile others need up to a month before they feel any difference.

Topamax is known to interact with other substances in a way that can be dangerous for patientsThe body digests Topamax in the liver and eliminates it from the body through the kidneysTaking other medicines that are digested in liver at the same time as Topamax may affect how quickly the drug works and leaves the bodyPeople with liver disease and people with a history of kidney stones must be cautious about taking the drug.

This medication can rarely cause a serious metabolic problemhigh amount of ammonia in the bloodespecially if you are also taking valproic acidTell your doctor right away if you experience sudden/unexplained tirednessvomitingor mental changessuch as decreased alertness

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