Drugs whose efficacy is impaired by phenytoin include azoles fluconazole, ketoconazole, itraconazole, voriconazole, posaconazole , corticosteroids, doxycycline, estrogens, furosemide, irinotecan, oral contraceptives, paclitaxel, paroxetine, quinidine, rifampin, sertraline, teniposide, theophylline, and vitamin d.
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
You should know that your mental health may change in unexpected ways when you take paroxetine or other antidepressants to treat depression or other mental illness even if you are an adult over 24 years of ageYou may also experience changes in your mental health if you are a woman taking a low dose of paroxetine to treat hot flashes and you have never had depression or another mental illnessYou may become suicidalespecially at the beginning of your treatment and any time that your dose is increased or decreasedYouyour familyor your caregiver should call your doctor right away if you experience any of the following symptomsnew or worsening depressionthinking about harming or killing yourselfor planning or trying to do soextreme worryagitationpanic attacksdifficulty falling asleep or staying asleepaggressive behaviorirritabilityacting without thinkingsevere restlessnessand frenzied abnormal excitementBe sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.
Take the missed dose as soon as you rememberSkip the missed dose if it is almost time for your next scheduled doseDo not take extra medicine to make up the missed dose.
Bipolar disordermanic depressionor a history of drug abuse or suicidal thoughts;
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