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Palbociclib is also a weak time-dependent inhibitor of cyp3a and indinavir is a sensitive cyp3a4 substrate.

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Indirect hyperbilirubinemia has occurred frequently during treatment with CRIXIVAN and has infrequently been associated with increases in serum transaminasessee also ADVERSE REACTIONSClinical Trials and Post-Marketing ExperienceIt is not known whether CRIXIVAN will exacerbate the physiologic hyperbilirubinemia seen in neonatesSee Pregnancy

See Table 9 for steps to prevent or manage these possible and known significant drug interactionsincluding dosing recommendationsConsider the potential for drug interactions prior to and during CRIXIVAN therapyreview concomitant medications during CRIXIVAN therapyand monitor for the adverse reactions associated with the concomitant medications.

See your doctor regularly so that he/she can monitor your healthContinue to practise safer sex and take other precautions so as not to pass HIV on to other people.

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