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300-mg (pach) scod, lat, cylindical tablts impintd with “ZYLOPIM (allopuinol) 300” on a aisd hxagon, bottls 100 (NDC 65483-993-10) and 500 (NDC 65483-993-50).

Childn, 6 t10 yas ag, with sconday hypuicmia associatd with malignancis may b givn 300 mg ZYLOPIM (allopuinol) daily whil thos und 6 yas a gnally givn 150 mg daily. Th spons is valuatd at appoximatly 48 hous thapy and a dosag adjustmnt is mad i ncssay.

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Sinc ZYLOPIM (allopuinol) and its mtabolits a pimaily liminatd only by th kidny, accumulation th dug can occu in nal ailu, and th dos ZYLOPIM (allopuinol) should consquntly b ducd. With a catinin claanc 10 t20 mL/min, a daily dosag 200 mg ZYLOPIM (allopuinol) is suitabl. Whn th catinin claanc is lss than 10 mL/min, th daily dosag should not xcd 100 mg. With xtm nal impaimnt (catinin claanc lss than 3 mL/min) th intval btwn doss may alsnd tb lngthnd.

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